Read Donald A. Tomalia et al. (Download from Class Web) (1990 Angewandte Chemie 29, pp.138-175 : ) "Starburst Dendrimers" and answer the following questions.

Notation: <123> means page 123. thinking means you have to think about it.

1. Matter can be considered macroscopically (on human scale), microscopically (point molecules), and what is inbetween? Why is Tomalia interested in this scale? and what did he do to bridge the gap? Show his steps, 1,2,3, and 4. 2. What are the critical molecular design parameters (CMDPs)? 3. What 's the difference between the synthetic and the evolutionary strategies of CMDP? 4. Who is Mandelbrot? What did he do? <144> 5. What equations Tomalia derived to get the ternminal groups? No. of repeat units? No. of branch cells, and the molecular weight? Show them! <145> 6. How does one go about synthesizing a dendrimer? <147> 7. What are the sizes of a PAMAM at g=3,4, and 9? (CPK and SEC) <149> 8. What are the moieties on a polyether dendrimer? (see Schedule 4, <151>) 9. What is the moelcular structure (looks like) of PAMAM <154>. 10. What is the relation between the generation g and the dimension, dmax, of a dendrimer? <156> 11. Dendrimers made are plagued by polydispersity, Why? <158> 12. What's the difference between a starburst dendrimer and a starbranched polymer (e.g., a polypus, octapus shaped polymer)? <160> 13. What is a cleft in PAMAM? <164> 14. Is dendrimer a micelle? <165> 15. Why is dendrimer compared to a liposome? <166> 16. What are the analogies between dendrimers and biology? <167> 17. What is the importance of dendrimers to nanotechnology? <171> 18. After reading Tomalia 1990, do you think that you have come away with better understanding of the dendrimers? Did Tomalia do a good job? ---------------------------------------------------------------------